[BK세미나] 5/9(금) 한범수 교수(UIUC) "PDAC17: Engineered Microphysiological Systems for Translational Drug Discovery"

기계공학부 구성원들의 많은 관심과 참여 부탁드립니다.

▣ 주 제: PDAC17: Engineered Microphysiological Systems for Translational Drug Discovery

▣ 연 사: 한범수 교수

▣ 소 속: University of Illinois Urbana-Champaign

▣ 일 시: 2025. 5. 9.(금) 15:00

▣ 장 소: 제4공학관 D604호

▣ 초 청: 류원형 교수

▣ 초 록

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer death in the US, with a dismal 13% five-year survival rate. This poor prognosis is attributed to its complex tumor microenvironment (TME) with a desmoplastic stroma, which facilitates tumor growth/invasion, drug delivery barrier and resistance, and immunosuppressive TME. Thus, the stroma has been targeted, but many of these strategies were not successfully translated. Even several recent studies have suggested the stroma may also have anti-tumor roles. In this context, my group performs translational engineering research to reprogram the PDAC stroma without compromising its anti-tumor roles. In this talk, I will present our recent effort to test a hypothesis that the coagulation system in the PDAC TME can be targeted to reprogram PDAC stroma. We have been developing new microphysiological systems (MPS) of the normal and cancerous pancreas. In conjunction with genetically engineered cells and preclinical animal models, the PDAC MPS platforms are further used to identify the role of key molecular targets of the coagulation system and to evaluate the effects of their pharmacological inhibition to develop effective strategies to reprogram the PDAC stroma.