[BK세미나] 8/18(월) 김성찬 교수(경상국립대학교 약학대학) "Engineering Non-Viral Vector Platforms for In Vivo Gene Editing in Cancer Therapy"

기계공학부 구성원들의 많은 관심과 참여 부탁드립니다.

▣ 주 제: Engineering Non-Viral Vector Platforms for In Vivo Gene Editing in Cancer Therapy

▣ 연 사: 김성찬 교수

▣ 소 속: 경상국립대학교 약학대학

▣ 일 시: 2025. 8. 18.(월) 13:30

▣ 장 소: 제4공학관 D604호

▣ 초 청: 류원형 교수

▣ 초 록

Overcoming biological barriers remains a critical challenge in the clinical translation of RNA and protein-based therapeutics. Non-viral delivery systems, particularly structure-engineered nanoparticles (NPs), offer a scalable, biocompatible, and tunable platform forin vivo gene editing applications. This presentation will focus on the rational design and surface modification strategies of NPs to enable efficient loading, protection, and controlled release of gene editing agents such as CRISPR components. Enhanced physicochemical properties—including size, pore structure, and surface chemistry— enable targeted delivery to tumor tissues with minimal off-target effects. Evaluation study in rodent models demonstrates promising efficacy across multiple administration routes.The integration of materials science and biomedical engineering in this platform establishes a foundation for next-generation cancer gene therapeutics with improved safety, specificity, and translational potential.